Evidence regarding the need for effective treatment of Major Depressive Disorder with associated Subjective Cognitive Decline*

*Flatt et al, Alzheimer’s Dement. 2021;7:e12197.

Indicating need for effective treatment of Major Depressive Disorder with associated Subjective Cognitive Decline (MDD-SCD).

Intro:

Abstract
Introduction: Subjective cognitive decline (SCD) represents self-reported problems with memory, a possible early sign of dementia. Little is known about SCD among sexual and gender minority (SGM) adults who identify as lesbian, gay, bisexual, and/or transgender or gender non-binary.
Methods: Data were weighted to represent population estimates from 25 states’ 2015–2018 Behavioral Risk Factor Surveillance System to describe SCD in adults ≥45
years by SGM status. Logistic regression tested associations between demographic and health conditions.


Results: SCD prevalence was higher in SGM (15.7%; 95% confidence interval [CI]:13.1–18.2) than in non-SGM adults (10.5%; 95% CI:10.1–10.9; P < .0001). SGM
adults with SCD were also more likely to report functional limitations due to SCD than non-SGM adults with SCD, 60.8% versus 47.8%, P = .0048. Differences in SCD by SGM status were attenuated after accounting for depression. Discussion: Higher prevalence of SCD in SGM adults highlights the importance of ensuring inclusive screenings, interventions, care services, and resources for SGM adults.


The Status of ANT01 and ANeuroTech

23 February 2022
FDA GRANTED ANT01 PHASE IIIB STUDY PROGRAM IN PARTIAL RESPONSIVE DEPRESSION (PRD).

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