Evidence regarding the need for effective treatment of Major Depressive Disorder with associated Subjective Cognitive Decline*

*Flatt et al, Alzheimer’s Dement. 2021;7:e12197.

Indicating need for effective treatment of Major Depressive Disorder with associated Subjective Cognitive Decline (MDD-SCD).

Intro:

Abstract
Introduction: Subjective cognitive decline (SCD) represents self-reported problems with memory, a possible early sign of dementia. Little is known about SCD among sexual and gender minority (SGM) adults who identify as lesbian, gay, bisexual, and/or transgender or gender non-binary.
Methods: Data were weighted to represent population estimates from 25 states’ 2015–2018 Behavioral Risk Factor Surveillance System to describe SCD in adults ≥45
years by SGM status. Logistic regression tested associations between demographic and health conditions.


Results: SCD prevalence was higher in SGM (15.7%; 95% confidence interval [CI]:13.1–18.2) than in non-SGM adults (10.5%; 95% CI:10.1–10.9; P < .0001). SGM
adults with SCD were also more likely to report functional limitations due to SCD than non-SGM adults with SCD, 60.8% versus 47.8%, P = .0048. Differences in SCD by SGM status were attenuated after accounting for depression. Discussion: Higher prevalence of SCD in SGM adults highlights the importance of ensuring inclusive screenings, interventions, care services, and resources for SGM adults.


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